The Silver Case takes place in 1999 in the (fictional) 24th Ward of Tokyo, where the murderer Kamui Uehara committed the titular Silver Case twenty years prior. He's thought to now be harmless, until he escapes from the mental hospital at which he's being detained. We play as the unnamed sole survivor of the unit first dispatched to recover Kamui, who then finds himself swept up into the 24th Ward's Heinous Crimes Unit, which investigates... heinous crimes.